Tag: Central Nervous System
Multi-phase Multi-layer MechDermA Model: Development, Verification and Application of a PBPK/PD Model of Dermal Absorption for Transdermal Product Assessment
Certara VP to Co-chair NIH Workshop on the Use of QSP to Enhance CNS Drug Discovery and Development
PRINCETON, NJ – 7월 25, 2017 – Certara today announced that Professor Piet van der Graaf, PharmD, PhD, vice president and head of Certara QSP, is co-chairing the NIH workshop entitled “QSP and Drug Discovery: Filling the Gaps in Current Models of the R&D Process for Neurotherapeutics.”
Population Pharmacokinetic of L-DOPA and Its Main Metabolites: Use of the Phoenix-based QRPEM Algorithm
Predicting Diclofenac Systemic and Synovial Fluid Concentrations After Dermal Application Using the Multi-phase Multi-layer MechDermA PBPK Model
Effect of Disease-related Changes in Plasma Albumin on the Pharmacokinetics of Naproxen in Male and Female Arthritic Rats
Quantify Chronic Lower Back Pain Clinical Outcomes Database
The current version of the database includes clinical safety and efficacy information on treatment options currently approved or in development for chronic lower back pain. The current version of the database includes information on all systemic pharmacological interventions. This includes mono and combination therapy with NSAIDs, acetaminophen, opioids, COX-2 inhibitors, norepinephrine reuptake inhibitors, anti-NGF, anti-epileptic drugs (AEDs), antidepressants, and muscle relaxants.
Quantify Multiple Sclerosis Clinical Outcomes Database
The current version of the database includes clinical safety and efficacy information on disease modifying therapies that are on the market or late stage clinical development for relapsing, remitting, and secondary progressive multiple sclerosis.
Quantify Neuropathic Pain Clinical Outcomes Database
The current version of the database includes clinical safety and efficacy information on treatment options currently approved or in development for painful diabetic neuropathy (DPN), post herpetic neuralgia (PHN), or fibromyalgia. Information on older treatment options (such as tricyclic antidepressants) was included if they are used as active controls.
Changing the Game in Drug Development: A Selection from Certara’s Best of Blogs
A selection of short essays from our blog containing insights from our thought leaders on how modeling and simulation has impacted and is continuing to reshape our approach to drug development.
