Vigabatrin is an inhibitor of γ-aminobutyric acid transaminase. The purpose of these analyses was to develop a population pharmacokinetics model to characterize the vigabatrin concentration–time profile for adults and children with refractory complex partial seizures (rCPS) and for children with infantile spasms (IS); to identify covariates that affect its disposition, and to enable predictions of systemic vigabatrin exposure for patients 1–12 months of age.
Population Pharmacokinetics Analysis of Vigabatrin in Adults and Children with Epilepsy and Children with Infantile Spasms
11월 1, 2014
Author(s): Jace Nielsen, Kenneth Kowalski, Aziz Karim, Mahlaqa Patel, David Wesche, Dwain Tolbert
Year: 11월 1, 2014