This comprehensive review exposes gaps in current knowledge of phase II enzyme and drug transporter localization, expression, and regulation during pregnancy, which emphasizes the need for further research. The information collected will aid in optimizing pregnancy PBPK models to inform dose selection in pregnancy population.
A Literature Review of Changes in Phase II Drug-Metabolizing Enzyme and Drug Transporter Expression during Pregnancy
1월 3, 2024
Author(s): Christine Gong, Lynn N. Bertagnolli, David W. Boulton, Paola Coppola
Year: 11월 15, 2023