Year: 2020

More than 50 bispecific antibodies are in oncology clinical development with a large diversity in formats, directed at a range of immune and tumor targets. Bispecifics have demonstrated the potential for enhanced efficacy and reduced systemic toxicity. However, they are complex modalities with challenges to overcome in early clinical trials, including selection of relevant starting … Continued

Most drug labels do not provide dosing guidance for pregnant and lactating women, yet in the U.S. alone, more than 6 million women are pregnant each year, and it is estimated that more than 90 percent take at least one medication while pregnant or lactating. Simcyp has developed and published papers on its time varying … Continued