Month: June 2015
Simcyp In Vitro (Data) Analysis (SIVA) Toolkit: Deciphering Dissolution Experiments and Translating Intrinsic Parameters into PBPK Models
A New Method to Quantify Population Variability for Toxicity Testing
Historically, toxicity testing has been conducted by giving lab animals high doses of chemicals and observing them for adverse events. But quantifying the risks chemicals pose to humans based on animal studies is problematic as the chemical doses are often orders of magnitude higher than environmental levels. Moreover, this process is slow, expensive, and ethically … Continued
Mapping In Vitro and In Vivo Derived CYP2C9 and CYP2C19 Ontogeny Functions: A Critical Comparison Between Various Ontogeny Models
Prediction of the Oral Clearance of Isoniazid in Virtual Subjects With Different Nat-2 Acetylator Status
Evaluation of the Drug-drug Interaction Between Zidovudine and Probenecid by Using a Mechanistic Kidney Model (Mech KiM) Nested Within a Full Physiologically-based Pharmacokinetic (PBPK) Model
Towards Quantitative Prediction of Disease-drug Interactions Using a Physiologically-based Pharmacokinetic Modeling Approach: Suppression of CYP1A2 by IL-6
Application of a Multi-compartment Permeability Limited Lung Model to Predict Lung Concentrations of Anti-Tuberculosis Drugs in Virtual Human Subjects
Application of an LC-MS/MS Method for the Simultaneous Quantification of Human Intestinal Transporter Proteins Absolute Abundance Using a QconCAT Technique
Transporter proteins expressed in the gastrointestinal tract play a major role in the oral absorption of some drugs, and their involvement may lead to drug-drug interaction (DDI) susceptibility when given in combination with drugs known to inhibit gut wall transporters. Anticipating such liabilities and predicting the magnitude of the impact of transporter proteins on oral drug absorption and DDIs requires quantification of … Continued
