Year: 2011
A Mechanistic Model for the Prediction of Human Equilibrium Blood-to-plasma Concentration Ratio (B/P): Basic and Neutral Drugs
A Performance Evaluation of Simcyp PBPK Dog Model based upon a Variety of Theophylline IV and Oral Formulations
P-gp Efflux Has No Impact on Dose Proportionality of Digoxin Bioavailability over a Dose Range of 0.125 To 1.5 Mg: The Outcome of a New PBPK Model, That Includes the In Vitro Transporter Information, is Consistent with the Clinical Observations
An Investigation into the Prediction of In Vivo Clearance for a Range of Aldehyde Oxidase Substrates Using a Mechanistic Population-based Pharmacokinetic Model
Safety and Population Pharmacokinetic Analysis of Intravenous Acetaminophen in Neonates, Infants, Children, and Adolescents with Pain or Fever
The administration of acetaminophen via the oral and rectal routes may be contraindicated in specific clinical settings. Intravenous administration provides an alternative route for fever reduction and analgesia. This phase 1 study of intravenous acetaminophen (Ofirmev, Cadence Pharmaceuticals, Inc., San Diego, CA) in inpatient pediatric patients with pain or fever requiring intravenous therapy was designed … Continued
Risk Assessment of Accidental Nortriptyline Poisoning: The Importance of Cytochrome P450 for Nortriptyline Elimination Investigated Using a Population-based Pharmacokinetic Simulator
It is not possible to make a prospective clinical study that reveals the importance of the nortriptyline metabolising cytochrome P450 (CYP) isoforms (CYP1A2, CYP2C19, CYP2D6, and CYP3A4) in relation to attaining potential toxic nortriptyline concentrations with a possibly fatal outcome. Therefore to study this we have applied the population based pharmacokinetic simulator Simcyp®. The objective … Continued
Certara to Distribute Leading Software for Predicting Off-Target Effects of Small Molecules
Partnership with Chemotargets to support systems drug discovery ST. LOUIS, MO – October 5th, 2011 – Certara™, a leading provider of software and services to improve productivity and decision-making from drug discovery through clinical development, announced that it will be the exclusive provider of Chemotargets software for predicting the off-target pharmacology of small molecules. Chemotargets … Continued
Evaluation of Combined Bevacizumab and Intraperitoneal Carboplatin or Paclitaxel Therapy in a Mouse Model of Ovarian Cancer
The purpose of this was to evaluate the pharmacokinetics of bevacizumab following IP and IV administration, and to investigate combined bevacizumab therapy (IP or IV) with IP paclitaxel or carboplatin in a mouse model of ovarian cancer. Bevacizumab pharmacokinetics were investigated following IV or IP dosing, and mice bearing peritoneal A2780 xenografts were treated with … Continued
Pharmacokinetics of SN2310, an Injectable Emulsion that Incorporates a New Derivative of SN-38 in Patients with Advanced Solid Tumors
SN2310 is an injectable emulsion composed of vitamin E, a succinate derivative, as well as 7-ethyl-10-hydroxycamptothecin (SN-38), the active metabolite of irinotecan. Single intravenous doses of 15, 20, 25, and 30 mg/m2 of SN2310 emulsion were administered in a total of 26 patients with advanced solid malignancies.