Drug Interaction Solutions Consulting Services
Drug Interaction Solutions Consulting Services
Draw on drug interaction expertise to improve clinical decision making and maximize the value of your Drug Interaction Database (DIDB) license
With the scientist-curated DIDB at their fingertips, Certara’s expert drug interaction consultants are available to help pharmaceutical researchers and regulatory scientists decode drug interactions, improve clinical decision making, and ultimately, enhance patient safety.
Our Drug Interaction Solutions (DIS) team offers services related to the systemic evaluation of the literature and NDA reviews to assess the risk of human pharmacokinetic (PK) drug-drug, food-drug, gene-drug and disease-drug interactions.
Examples of possible analyses include, but are not limited to
Detailed mechanistic assessment of risk
of DDIs between a drug candidate and known substates and perpetrators or enzymes and transporters (including food and herbal products).
Review of the literature and NDAs
to guide DDI study design (in vitro evaluations, clinical studies and more).
Evaluation of PK variability
of common drug substrates to guide calculation of the number of subjects.
Impact of hepatic and renal impairment
understanding the impact of hepatic and renal impairment on drug exposure.
Impact of gene polymorphism of enzymes and transporters
understanding the impact of gene polymorphism of enzymes and transporters on drug exposure.
Insight on complex DDI mechanisms
provide insight on complex mechanisms of DDIs based on most up-to-date scientific and mechanistic knowledge.